Lesson Code: BPU-1104 (PREMIUM LESSON) Describes the function, design, set-up and control of bioreactors in the biopharmaceutical industry. It examines control parameters such as heat management, pH, oxygen, mass transfer, and agitation, and how the type of cells being produced impacts on bioreactor set up and control. It also introduces the meaning of sterility, and bioreactor cleaning using CIP.

  • Category: Biopharma Processes and Equipment


After completing this e-Lesson you will be able to:

  • Describe the purpose of a bioreactor in bioprocessing
  • Describe the structure of a typical stainless steel bioreactor
  • Distinguish between the different operating modes of a bioreactor
  • Explain how effective mixing can be achieved in a bioreactor
  • List the process parameters that are typically monitored and controlled when operating a bioreactor
  • Describe the various risk factors that can compromise bioreactor sterility and how contamination of a bioreactor can be prevented
  • Explain the concept of 'mass transfer' in bioprocessing
  • Explain the relationship between metabolism, heat generation, and agitation in bioprocessing