HPLC Troubleshooting

Lesson Code: PPL-831. Describes the troubleshooting of common HPLC equipment problems. Examples include leaks, column frit blockages, baseline noise and detector malfunctions. The Lesson also describes the approach to troubleshooting these commonly encountered problems, and will be an invaluable resource to anyone working with HPLC on a regular basis.

  • Category: Analytical Laboratory - Practices


After taking this e-Lesson, you will be able to:

- Recognize and respond to the most commonly encountered problems that can occur when operating HPLC equipment

- Describe the critical actions an analyst should take to minimize the occurrence of known issues with HPLC

- Describe troubleshooting practices for each component of the HPLC

- Explain the importance of preventative maintenance