Understanding Dissolution

Lesson Code: PPL-1210. This e-Lesson is aimed at personnel who require an overview of dissolution testing, including the factors that affect dissolution, and how a solid dosage drug form is absorbed into the bloodstream. 'In Vivo' and 'In Vitro' analyses are explained and typical 'In Vitro' dissolution tests are described.

  • Category: Analytical Laboratory - Practices

Description

After taking this e-Lesson, you will be able to:

  • Define the term 'dissolution'
  • Explain the purpose of dissolution testing
  • List and describe the factors that affect dissolution
  • Describe what happens to a solid dosage drug form in the human body after it is swallowed
  • Explain the difference between 'in vivo' and 'in vitro' dissolution analysis
  • Explain why in vitro dissolution analysis is important
  • Explain the difference between single-point and multi-point dissolution tests

KEYWORDS: Absorption, Disintegration, Dissolution, Gastrointestinal Tract, In Vitro, In Vivo, Multipoint, pH, Polarity, Single-Point, Solubility, Temperature